Sr. Principal Scientist - Toxicology Project Team Representative

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr. Principal Scientist - Toxicology Project Team Representative

What you will do

Let’s do this. Let’s change the world. Amgen’s Translational Safety and Risk Sciences (TSRS) function is actively seeking a talented Senior Principal Scientist to join the Portfolio, Pharmacology, & Data Sciences (PPDS) Team as a TSRS Project Team Representative (PTR). The Senior Principal Scientist will provide scientific leadership and play an active role in the process of drug development from late-stage discovery through marketed products. Working in a collaborative team environment, in this vital role you will contribute to the safety assessment of small molecule and biologic therapeutics by synthesis of existing knowledge and comprehensive investigations of toxicological activity. Amgen TSRS PTRs make significant contributions to multiple teams, work in multiple therapeutic areas, and mentor and motivate other staff members.

Responsibilities include:

• Participate and contribute toxicology, safety and other subject matter expertise to key project teams. Provide regular updates as appropriate to project teams and management.
• As a PTR, design, implement, manage and analyze safety assessment programs in support of drug development candidates.
• Responsible for originating novel protocols to solve experimental questions and devising strategies/planning activities to achieve project goals.
• Critically evaluate and interpret results of scientific experiments and contribute to appropriate sections of internal governance documents, INDs, BLAs, NDAs and other regulatory documents.
• Coordinate and collaborate with other Amgen scientists and external organizations in facilitating research projects.
• May participate in licensing and due diligence activities.
• May mentor other Amgen staff for implementation and oversight of studies supporting research and development programs.
• May represent Amgen's nonclinical safety issues at national and international regulatory meetings. May participate in external industry initiatives to improve drug safety assessment paradigms.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The [vital attribute] professional we seek is a [type of person] with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR DVM OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of Toxicology, Pathology, Life Sciences or a related field

Or

Master’s degree and 6 years of Toxicology, Pathology, Life Sciences or a related field experience

Or

Bachelor’s degree and 8 years of Toxicology, Pathology, Life Sciences or a related field experience

Preferred Qualifications:

• 8+ years post-PhD degree of Pharmaceutical and/or Biotechnology industry experience and 5+ years as a Toxicology/Nonclinical Safety Project Team Representative.
• Experience leading toxicology research programs supporting safety assessment of drug development candidates.
• Experience in the preparation of regulatory documents and interactions with US and international regulatory agencies.
• Board certification in Toxicology.
• Excellent written and verbal communication skills, the ability to work independently and to build productive cross-functional collaborations both internally and externally.
• Working understanding of cutting-edge science and technology being used to enhance investigation of drug development safety issues.
• National and international recognition as a field expert.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.