Process Development Senior Scientist

Amgen is seeking a talented Process Development Senior Scientist with experience in the manufacturing of synthetic peptides, oligonucleotides, and/or antibody drug conjugates to join our Drug Substance Technologies - Synthetics (DSTS) group. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, characterization, and implementation of synthetic drug substance manufacturing processes and technologies to advance Amgen's exciting small molecule and hybrid portfolio. The Senior Scientist role will include supporting the development of efficient and sustainable manufacturing processes to prepare peptides, oligonucleotides, and/or antibody drug conjugates, driving technology innovation to support bioconjugation, and providing technical expertise towards manufacturing and commercialization.

Key Responsibilities:

• Work with a diverse team of synthetic chemists, chemical engineers and analytical chemists to develop sustainable and cost-effective processes for synthetic peptide, oligonucleotide, and/or antibody drug conjugate manufacturing
• Drive technology innovation in the synthesis, purification, and characterization of bioconjugates
• Support cGMP manufacturing and technology transfer to large-scale production facilities
• Develop strategies to ensure process performance through process understanding, modeling and characterization
• Guide successful completion of project deliverables and ensure timelines are met
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of peptide, oligonucleotide, and antibody drug conjugate manufacturing
• Coach and provide career and scientific / technical advice to colleagues within the organization
• Interface with Research / Discovery teams to advance programs into Process Development and towards clinical development milestones.

Basic Qualifications:

Doctorate degree in Chemistry, Biochemistry, or Chemical Biology

OR

Master’s degree in Chemistry, Biochemistry, or Chemical Biology and 5+ years of industry experience

Preferred Qualifications:

• Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bioconjugation techniques
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
• Proven track record of publications, patents and presentations