Scientist – Mass Spectrometry (Lead Discovery & Characterization)

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist Mass Spectrometry (Lead Discovery & Characterization)

What you will do

Let’s do this. Let’s change the world. Amgen is a biopharmaceutical leader founded on discovering, developing, manufacturing, and delivering innovative human therapeutics. Amgen's Lead Discovery and Characterization laboratory within Therapeutic Discovery is seeking a highly motivated small molecule Mass Spectrometry expert at Amgen headquarters in Thousand Oaks, CA.

Responsibilities:

The Scientist Mass Spectrometry will be responsible primarily for the development of label-free technologies to monitor and quantify protein-ligand interactions, including screening and characterizing small molecule ligands by Mass Spectrometry. Additional responsibilities may include the development and execution of mass spectrometric-based characterization of protein-small molecule adducts (e.g. native MS or affinity selection MS) as part of our efforts toward the discovery of new drugs.

The successful candidate will work closely with biology and chemistry teams to develop new assays and strategies, analyze results, and present and discuss high quality data in a timely manner and should also contribute to skills development and mentoring for colleagues in a highly multi-disciplinary environment.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek has these qualifications.

Basic Qualifications:

Doctoral degree

Or

Master’s degree and 2 years of scientific experience

Or

Bachelor’s degree and 4 years of scientific experience

Preferred Qualifications:

• Doctoral degree with 2 years of mass spectrometry experience and a background in quantitative Biochemistry, Cell and/or Molecular Biology, or closely related field.
• Deep knowledge of small molecule MS techniques, especially as applied to monitoring of enzyme reactions for quantitative analysis of protein-ligand interactions and hit identification by ASMS.
• Experience with the operation, troubleshooting, and maintenance of Q-TOF, QQQ, and/or MALDI mass spectrometers, including the use of LC, SPE, or SEC separation techniques.
• Experience in the development of LC-MS, LC-MS/MS, or SPE-MS methods for affinity selection-based MS assays, MS-detected enzyme assays, or to characterize protein-small molecule adducts by intact protein MS.
• Familiarity with Agilent, SCIEX, Bruker instrumentation and software, e.g. Agilent MassHunter and SCIEX MultiQuant software.
• Experience in the development of SPE-MS or MALDI-TOF methods for MS-detected enzyme assays, or to characterize protein-small molecule adducts.
• Fluency in data analysis using GraphPad PRISM, Excel and vendor software. Experience with high-throughput data analysis packages (e.g. Genedata Screener, Expressionist) is an advantage.
• Familiarity with the principles of high-throughput screening (HTS) and experience with microplate readers and automated liquid handling systems Agilent Bravo, Echo, Tecan).
• An understanding of mechanistic enzymology and biophysical assays (SPR, ITC, NMR) for characterization of protein-ligand binding.
• Demonstrated ability to work both independently and as a member of a multidisciplinary team.
• Excellent written and oral communication skills for the timely documentation, presentation, and discussion of science-based results and strategy in a dynamic, multi-disciplinary, team-based environment.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.