Principal Scientist - Bioanalytical Science

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist - Bioanalytical Science

What you will do

Let’s do this. Let’s change the world. The Translational Safety and Bioanalytical Sciences (TS&BA) organization is seeking to fill a Principal Scientist position in our LC-MS/MS Bioanalytical Sciences group at the Amgen Thousand Oaks site in California. In this role, you will implement robust LC-MS/MS bioanalytical methods to support a broad range of therapeutic agents, including small molecules, oligonucleotides, proteins, and other complex molecular entities. Given the scope of projects, the role will involve multidisciplinary interactions with scientist across research and development at Amgen. The position is lab based, and has significant emphasis on data management/fidelity, report generation, project-based leadership, and communication across multiple teams.

Key Responsibilities:

• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times.
• Conduct small and large molecule bioanalysis in non-clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using SPE, protein crash, and/or affinity capture methodologies.
• Author study reports, standard operating procedures, analytical methods, memos, and other regulatory-compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a highly collaborative, motivated scientist with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of relevant scientific experience

Or

Master’s degree and 5 years of relevant scientific experience

Or

Bachelor’s degree and 7 years of relevant scientific experience

Preferred Qualifications:

• Ph.D. in a relevant scientific discipline
• Prior GLP and GCP experience
• Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
• Strong technical expertise in quantitative mass spectrometry particularly on triple quadrupole (QQQ) platforms
• Broad experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation, low flow chromatographic approaches, high resolution mass spectrometry, and/or microsampling
• Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
• Demonstrated scientific breadth and subject matter expertise
• Supervisory and mentoring experience in a lab-based setting
• Ability to communicate complex scientific concepts across disciplines
• A strong background in quantitative analytical techniques
• Demonstrated scientific excellence, as evidenced by publications, external commitments (committees and presentation), and other achievements
• A desire to master bioanalytical business processes
• Excellent scientific problem-solving skills
• Excellent project and time management abilities
• Ability to work collaboratively with internal and external stakeholders

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.