Scientist – Discovery Proteomics

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist – Discovery Proteomics

What you will do

Let’s do this. Let’s change the world. In this vital role you will part of the Discovery Proteomics team. We are seeking a Scientist with expertise in liquid chromatography/mass spectrometry-based proteomics to work in South San Francisco. The team develops and implements proteomic technologies for Amgen’s early discovery pipeline programs and technology platforms. In this role, the Scientist will contribute to both discovery and targeted proteomic analyses for cell surfaceomics, proximity labeling, target validation, and mechanism-of-action studies. Expertise in modern mass-spectrometry based proteomic technologies and cell surface protein enrichment methods is required. Additional responsibilities include technology innovation and implementing methodologies to advance Amgen’s early discovery-stage therapeutic candidates.

This role will enable Amgen’s preclinical pipeline through delivery of innovative technologies and technical expertise.

Responsibilities

• Design and implement complex proteomics workflows, including sample preparation, liquid chromatography, and mass spectrometry for both discovery and targeted approaches (e.g., TMT, PRM, label-free DDA & DIA) to support cell surface target discovery.
• Use data processing software (e.g., Proteome Discover, Spectronaut, DIA-NN) and collaborate with the bioinformatics team for streamlined data sharing.
• Work closely with scientists across functions, present analysis results to stakeholders, collaborate on data integration, and utilize external resources as needed.
• Present research findings to colleagues, at scientific meetings (oral or poster presentations) and publish in peer-reviewed journals.
• Maintain detailed records of experiments, protocols, and analyses.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The [vital attribute] professional we seek is a [type of person] with these qualifications.

Basic Qualifications:

Doctorate degree or

Master’s degree and 4 years of scientific experience or

Bachelor’s degree and 6 years of scientific experience

Preferred Qualifications:

• A technical understanding of mass spectrometry and data analysis for quantitative proteomic research, including DDA, DIA, TMT, PTM analysis, with an emphasis on proximity labeling and cell surface proteomics.
• Demonstrated capability of troubleshooting and evaluating LC/MS performance.
• A proven track record of scientific innovation and accomplishment in mass spectrometry and proteomics, as demonstrated by a strong publication record and conference presentations.
• Experience in cell surface proteomic approaches including enrichment methods such as cell surface capture and photo catalytic proximity labeling.
• Function optimally in a team-based or collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills, and demonstrate the ability to produce reliable and reproducible results.
• Experience with automated sample handlers (e.g. Opentrons, Agilent Bravo AssayMAP, Kingfisher) or other high-throughput approaches.
• Demonstrated capability of working with diverse sample types including cell lines, tissues (mass-limited), biofluids and FFPE.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now

for a career that defies imagination

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.