WE ARE LOOKING FOR YOU

Amgen Research (Munich) GmbH, one of Amgen’s state-of-the-art research hubs located in the south of Munich and home to approximately 170 employees, is currently seeking a highly motivated and qualified:

Scientist / Senior Scientist (m/f/d)
Department: TSRS Nonclinical
Employment Type: Full-time, Fixed-term (3 years)
Start Date: As soon as possible

We are seeking a highly skilled and motivated scientist to join our Portfolio, Pharmacology and Data Sciences Department at the Scientist/Sr Scientist level. The successful candidate will conduct advanced research in the areas of 3D cell culture and organ-on-chip systems, creating in vitro cellular models and relevant assays for the safety evaluation of new drug candidates.

This role can be positioned either on GCF Level 5-1 (Scientist) or 5-2 (Senior Scientist), depending on professional qualification

and experience.

TASKS:

• Develop and implement new in vitro and ex vivo methods to support the development of New Approach Methodologies (NAMs) for nonclinical safety assessment.

• Application of 3D cell culture models (organoids/organs-on-a-chip technologies) that replicate various human organs (e.g., lung, lymph node, liver, pancreas, blood vessels, skin) and their associated diseases (e.g., cancer, autoimmunity) for drug screening and safety assessment applications.

• Characterization of 3D cell culture models using fluorescence microscopy, flow cytometry, or gene/protein expression.

• Qualifying 3D cell culture models for a particular use by quantifying their ability to predict known clinical outcomes.

• Conducting relevant cellular/molecule functional in vitro assays on the efficacy and toxicity of potential drug candidates (e.g., antibodies) utilizing plate-based immunoassays, FACS and cell-based imaging with minimal supervision.

• Develop hypotheses and design experimental plans to propose creative and novel solutions, execute experiments, and analyze and interpret results.

• Collaborate cross-functionally with various scientific teams, sharing ideas and proposing solutions for scientific and clinical challenges during regular group meetings and internal seminars.

• Engage in appropriate training of lab personnel and lab maintenance, including equipment maintenance and ordering supplies.

• Manage projects independently and contribute to their intellectual advancement.

• Stay updated on current literature in organoids and organs-on-a-chip technology and related fields.

Qualifications and requirements:

• Master's Degree with 3+ years of experience or PhD degree in cell biology, immunology, biochemistry, or related fields.

• In-depth knowledge and hands-on experience with cell cultures such as immortalized cells, particularly in 3D cell culture models and organs-on-a-chip technologies, including design, characterization, and validation as well as in cell-based assays, molecular biology, immunology, and biochemical techniques.

• Skilled in biomarker detection techniques, including ELISA and ELISPOT.

• Strong analytical and problem-solving skills.

• Excellent verbal and written communication skills in English and German, with a strong willingness to collaborate in a global environment.

• Preferably direct experience developing organoids or organs-on-a-chip model within academia or a model development company.

WHAT WE OFFER TO YOU

• Flexible working hours

• 38-hour work week

• 30 days of annual vacation

• Additional leave for special occasions (e.g., wedding, relocation, etc.)

• Access toEGYM Wellpassfor fitness and wellness

• Busuulanguage learning app subscription

• Meal subsidy of €1.50 per day

• Company pension plan:

  • 4% of monthly base salary up to the social security contribution ceiling

  • An additional 7% of monthly base salary above the contribution ceiling

• Childcare allowance of up to €120 per month

• Employee recognition program (awards ranging from €50 to €450)

• Employee Assistance Program (EAP) for personal and professional support