Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP)

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP)

What you will do

Let’s do this. Let’s change the world. Amgen is seeking a passionate and innovative Scientist to join the Induced Proximity Platform team in Thousand Oaks, CA. This role is at the frontier of discovery biology, leveraging induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases.

The successful candidate will bring expertise in cell surface target identification and validation, as well as target functionalization toward the development of multispecific medicines. You will play a key role in driving innovation, developing technologies, and integrating multi-omics approaches to advance Amgen’s discovery pipeline.

Key Responsibilities:

• Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins.
• Support target functionalization efforts toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies for these therapeutics.
• Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines, primary cells, tissues, etc.).
• Develop approaches to validate proximity at the membrane using techniques including proximity ligation assays (PLA), Alphascreen/AlphaLISA and co-immunoprecipitation assays.
• Develop high throughput copy number analysis and receptor quantification assays using flow cytometry.
• Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies.
• Support target validation using tag-based approaches and cell line engineering.
• Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets.
• Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts.
• Present findings internally and externally through team meetings, conferences, and peer-reviewed publications.
• Maintain detailed electronic lab notebooks and experimental records.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a [type of person] with these qualifications.

Basic Qualifications:

• Doctorate degree or
• Master’s degree and 2 years of relevant scientific experience or
• Bachelor’s degree and 4 years of relevant scientific experience

Preferred Qualifications:

• Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques.
• Expertise in cellular proximity-based assays like PLA and Alphascreen/AlphaLISA technology.
• Experience in cell line generation and overexpression systems (e.g., lentiviral delivery) and functional validation of targets using cell-based assays.
• Experience working with large molecule therapeutics or hybrid modalities such as bispecific antibodies, T-cell engagers, or antibody-drug conjugates (ADCs).
• Familiarity with high-throughput automation platforms (e.g., Agilent Bravo), high-content imaging platforms and analysis software.
• Track record of scientific innovation as demonstrated by publications, patents, and/or conference presentations.
• Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams.
• Excellent verbal, written, and organizational skills.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.