ADC Development: Organic and Conjugation Chemist

HOW MIGHT YOU DEFY IMAGINATION?

Do more with the knowledge you’re working hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Through this program, you will acquire the valuable hands-on skills and foundational experience to become the professional you are meant to be in your chosen field.

Senior Scientist – Protein Engineering – ADC Development: Organic and Conjugation Chemist

This could be your everyday

Let’s do this. Let’s change the world.

The hybrid Modality Group in the Protein Engineering Department at Amgen is seeking a highly motivated organic chemist to join us in the state-of-the-art research facility at the Amgen headquarters campus located in Thousand Oaks, CA. The qualified candidate will work at the interface of synthetic chemistry, biochemistry, and chemical biology to apply their synthetic skills in developing ADC therapeutics and cutting-edge novel modalities. 

• Responsibilities including (but not limited to) the design, synthesis, purification and characterization of novel organic linkers, peptides, and payloads for antibody drug conjugates.
• Design, synthesis, purification, and characterization of antibody drug conjugates for therapeutic discovery.
• The scientist will review, analyze, and interpret scientific data and results; provide regular updates, documentation, and/or communication on project results.

Win

Here’s what it takes to Win

We are all different, yet we all use our unique contributions to serve patients. The dedicated individual we seek is a scientist with these qualifications.

Basic qualifications

• Doctorate degree specializing in organic chemistry, biochemistry, chemical biology, medicinal chemistry OR
• Master’s degree and 3 years of laboratory experience OR
• Bachelor’s degree and 5 years of laboratory experience

Preferred qualifications

• Posdoc or 2 years of synthetic chemistry experience preferred.
• Experience in the synthesis and purification of ADC linker and payloads.
• Experience in bioconjugation process is preferred.
• Experience with peptide synthesis and purification is preferred.
• A robust understanding of structural determination using NMR and MS techniques and proficient with a range of chromatography methods (e.g. HPLC, RP HPLC, ion exchange, size exclusion chromatography)
• Demonstration of good lab practices, with particular attention to safety

• Strong written and verbal communication skills
• Ability to work comfortably within a large team of scientists and engineers with diverse technical and cultural backgrounds.

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment, and inclusion in all that we do.

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey.
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.