R&D Pharmacokinetics and Drug Metabolism - Grad Intern

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

R&D Pharmacokinetics and Drug Metabolism - Grad Intern

What You Will Do

Let’s do this. Let’s change the world. During this program, you will join the Pharmacokinetics and Drug Metabolism & Bioanalytical Sciences (PKDM-BA) group based in South San Francisco, CA. The PKDM-BA organization is dedicated to understanding the absorption, distribution, metabolism, and elimination (ADME) properties of novel drug candidates to enable the discovery and development of innovative therapies.

The intern will work in a cross-functional team to evaluate and develop experimental workflows that characterize protein–protein interactions and target occupancy for protein therapeutics. This work will support mechanistic understanding of drug–target engagement and guide translational decision-making. Specifically, the intern will develop and apply immunoaffinity capture and/or crosslinking mass spectrometry (XL–MS) workflows to characterize protein complexes and derive quantitative readouts of target engagement.

• Designing and testing different approaches to quantify target occupancy, including immunoaffinity capture, crosslinking mass spectrometry (XL–MS), and LC–MS–based proteomic analyses.
• Developing and optimizing sample preparation workflows to capture protein–drug complexes from biological matrices.
• Implementing LC–MS/MS methods for detection and quantitation of target-bound and target-unbound species.
• Evaluating data quality and comparing performance across experimental strategies to identify robust approaches for target occupancy assessment.
• Collaborating with PKDM scientists and cross-functional teams to integrate findings into drug discovery and development pipelines.
• Summarizing literature, designing experiments, analyzing data, and presenting results to the scientific community within Amgen.

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. We are seeking a highly talented, creative and motivated summer intern with these qualifications:

Basic Qualifications:

Amgen requires that all individuals applying for a grad internship at Amgen must meet the following criteria:

• 18 years or older
• Graduated with a bachelor’s degree from an accredited college or university
• Currently enrolled in an MBA program for an MBA internship OR a Master’s program for a Master’s internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Master’s OR Pharm D OR Ph.D. program before the internship starts
• Enrolled in an accredited college or university following the potential internship
• Must not be employed at the time the internship starts
• Student must be located in the United States for the duration of the [internship

Preferred Qualifications:

• Hands-on experience in protein–protein interaction analysis and mass spectrometry–based proteomics.
• Familiarity with immunoaffinity enrichment, crosslinking chemistry, and LC–MS–based proteomic workflows.
• Demonstrated ability to analyze, interpret, and communicate experimental data clearly.
• Highly motivated and enthusiastic about experimental science and problem solving in a collaborative environment.

What You Can Expect of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $30-$40 per hour

• Build a network of colleagues that will endure and grow throughout your time with us and beyond.
• Bring your authentic self to the table and become the professional you’re inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
• Participate in executive and social networking events, as well as community volunteer projects.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com - Please search for Keyword R-230845

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Sponsorship

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.