Sr Mgr Mfg Systems Eng

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Manager Manufacturing Systems Engineering

What you will do

Let’s do this. Let’s change the world. This strategic leadership role is accountable for building, managing, and evolving the global MES COE, overseeing MES and adjacent systems deployments, lifecycle management, and governance for all manufacturing sites across Amgen’s network.

As the Sr Manager, you will direct a high-performing team of MES engineers, and technical specialists, ensuring the effective delivery and continuous improvement of MES solutions. You will partner with cross-functional leaders in Digital, Technology & Innovation, Operations, Quality, IT, and Automation to drive Amgen’s NextGen MES strategy—from vision through execution—supporting seamless integration with SAP, automation, cloud, and data platforms.

Your leadership will ensure standardization, compliance, and technical excellence, enabling Amgen’s digital transformation and operational agility on a global scale.

Roles & Responsibilities

• Lead and manage the global MES Center of Excellence (COE), including strategy, team building, performance management, and talent development.

• Oversee and execute the global MES roadmap and lifecycle strategy, ensuring alignment with Amgen’s business objectives and digital transformation initiatives.

• Establish and enforce best-in-class standards, methodologies, and governance for MES architecture, integration, cybersecurity, data integrity, and regulatory compliance (e.g., GxP, CFR Part 11).

• Drive harmonization of MES business processes and technical implementations across global sites, leveraging ISA-95 and other relevant manufacturing standards.

• Guide the evaluation and adoption of emerging technologies (e.g., IIoT, data lakes, AI/ML, containerization) to enhance MES capabilities and support advanced manufacturing use cases.

• Oversee the solution architecture, design, deployment, and lifecycle management of NextGen MES platforms—with a focus on PAS|X, SAP integration, automation interfaces, and cloud adoption—across all manufacturing sites.

• Serve as a steering member and customer concern point for all major MES projects, system incidents, and strategic vendor relationships.

• Develop and manage COE resource plans, budgets, and external partnerships to meet organizational objectives.

• Foster a culture of innovation, knowledge sharing, and continuous improvement within the COE and the wider global MES community.

• Ensure comprehensive documentation, knowledge management, and training programs to support global system adoption and sustainability.

• Champion change management strategies to enable successful MES transformation and adoption at all levels of the organization.

• Represent Amgen MES strategy and practices to senior leadership, regulatory agencies, and external partners as required.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients.

Basic Qualifications:

• Doctorate degree / Master's degree / Bachelor's degree and 12 to 17 years Engineering, Computer Science, Information Systems, or a related field.

• Minimum 8 years of hands-on experience with MES solution architecture, deployment, and lifecycle management in a GMP-regulated pharmaceutical, biotechnology, or manufacturing environment.

• Extensive experience with PAS|X MES (including v3.3 or higher), SAP integration, and Level 2/3 automation systems.

• Proven track record leading global, multi-site MES transformation programs, including direct management and mentorship of technical teams.

• Deep understanding of GxP regulations, CSV/validation, and SDLC standard methodologies.

• Demonstrated expertise with IT/OT cybersecurity, data integrity, cloud-based architectures, and emerging digital manufacturing platforms (e.g., IIoT, AI/ML, data lakes).

• Strong financial and vendor management experience.

• Excellent communication, relationship-building, and collaborator engagement skills at all levels, including executive leadership.

Preferred Qualifications:

• Expertise with Korber PAS|X MES, including eBR, Equipment Management, Weigh & Dispense, etc.

• Familiarity with international MES standards (ISA-95, GAMP, etc.).

• Experience representing MES programs with regulatory agencies and external partners.

• Experience with SAP MES integration and automation platforms (Rockwell, DeltaV, OPC UA, Pi).

• Proficiency with modern data platforms (PostgreSQL, data lakes, data fabric) and containerized application deployment (e.g., Kubernetes).

• Professional certifications (MES, SAP, Project Management/PMP, or equivalent).

Soft Skills

• Visionary leadership with a passion for nurturing technical talent and high-performing teams.

• Strategic thinking, adaptability, and a growth mindset.

• Exceptional organizational, analytical, and problem-solving abilities.

• Resilience in a dynamic, fast-paced, and global environment.

• Commitment to diversity, inclusion, and fostering a collaborative culture.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.