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Senior Project Manager, Operational Readiness

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Senior Project Manager, Operational Readiness

US - North Carolina - Holly Springs Apply Now
JOB ID: R-246224 País: US - North Carolina - Holly Springs Estado: On Site DATE POSTED: Jun. 01, 2026 CATEGORÍA DE EMPLEO: Project Management SALARY RANGE: 137,340.45USD -185,813.55 USD

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

SENIOR PROJECT MANAGER, OPERATIONAL READINESS

What you will do

Let’s do this. Let’s change the world. In this vital role you will have a central role as part of our start up team, leading the planning, execution and tracking of cross-functional activities for our operational readiness workstream, as well as overseeing and ensuring integration and alignment with Construction and Commissioning/Qualification workstreams.

Specific responsibilities include developing and integrating readiness plans for multiple workstreams, facilitating activities execution, owning program level forums and governances, resolving execution challenges, ensuring safety, quality and compliance objectives are met. Also, you will be responsible for resource planning and budgeting, active schedule and risk management, project communications, partner alignment, performance tracking, and lessons learned documentation.

  • Define project scope and develop operational readiness plans, schedules, and risk registers across key workstreams (Manufacturing, Engineering, Process Development, Supply Chain, Quality Assurance, Quality Control)
  • Plan and manage project resources, including forecasting, negotiation, reconciliation, and reporting
  • Integrate workstream plans into a consolidated master schedule to define and manage the overall critical path
  • Ensure alignment of operational readiness schedules internally and with construction and commissioning/qualification (C&Q) workstreams
  • Lead and facilitate execution across workstreams, maintaining accurate and up-to-date schedules
  • Proactively identify, manage, and resolve risks and issues; escalate as needed to maintain project milestones and deliverables
  • Establish and implement governance structures and tools to ensure effective oversight and decision-making across all workstreams
  • Lead cross-functional workshops to drive alignment, resolve challenges, identify gaps, and advance site strategy
  • Own the project communication strategy, including standardized tools for tracking, monitoring, and reporting progress
  • Provide regular, clear updates to stakeholders, including workstream leads and senior leadership
  • Provide strategic guidance to optimize project delivery, proactively de-risk execution, and align with site objectives

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The high-performing professional we seek is a an effective leader with strong cross-functional project management and communication skills, as well as the below with these qualifications.

Basic Qualifications:

  • High school diploma / GED and 12 years of Project Management experience OR
  • Associate’s degree and 10 years of Project Management experience OR
  • Bachelor’s degree and 6 years of Project Management experience OR
  • Master’s degree and 4 years of Project Management experience OR
  • Doctorate degree and 2 years of Project Management experience.

Preferred Qualifications:

  • Experience managing projects in the biopharmaceutical industry, preferably within biotechnology drug substance manufacturing
  • Proven ability to translate strategic objectives into clear, executable plans
  • Demonstrated leadership skills with the ability to set direction, establish high expectations, and drive performance
  • Experience defining workstream scope, roles, and responsibilities, and resolving ownership gaps or conflicts
  • Strong ability to build effective working relationships and partnerships across all organizational levels
  • Strong communication skills with the ability to engage project teams, workstream leads, senior leadership, and external partners
  • Self-starter with the ability to manage multiple projects simultaneously, from daily execution to program-level oversight
  • Experience leading large-scale projects within a matrixed organization
  • Ability to operate effectively in fast-paced environments with tight timelines
  • Strong negotiation and influencing skills across cross-functional stakeholders
  • Data-driven decision-maker with strong analytical and problem-solving capabilities
  • PMP certification preferred

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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