Principal Engineer - Global Reliability Network Lead (Remote)

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Engineer - Global Reliability Network Lead

What you will do

Let’s do this. Let’s change the world! In this vital role, you will lead Amgen’s Global Reliability Network as part of Engineering Operations Services (EOS) department, helping sites turn reliability data, maintenance history, failure trends, and equipment performance insights into actions that improve asset reliability, equipment availability, maintenance effectiveness, and operational capacity. You will also serve as the business lead for the CMMS Asset Performance Monitoring module and reliability-focused equipment insight tools across Amgen’s manufacturing network. Occasional on-site presence at the nearest Amgen operation site may be requested based on business needs.

Specific responsibilities include but are not limited to:

Lead the Global Reliability Network

• Lead a network of site reliability engineers, maintenance leaders, system owners, and technical SMEs.
• Develop and execute the Reliability Network strategy, goals, milestones, and maturity plans.
• Share reliability KPIs, bad actor trends, equipment improvements, lessons learned, and reusable solutions.
• Represent reliability priorities and recommendations in senior engineering governance forums.

Turn data insights into equipment improvements

• Use CMMS data, Asset Performance Monitoring, Plant Pulse, PdM findings, and site input to identify recurring failures, high-risk assets, downtime drivers, and bad actors.
• Convert reliability insights into corrective actions, equipment improvements, PM/PdM optimization, spare parts strategies, and capital recommendations.
• Track improvement actions, verify benefits, and scale successful practices across sites.

Advance asset criticality and maintenance strategy

• Define and maintain a standard risk-based asset criticality approach across sites.
• Use criticality to prioritize maintenance strategies, work execution, spare parts, lifecycle planning, and performance monitoring.
• Standardize maintenance strategies based on criticality, failure modes, operating context, and performance history.
• Support RCM, FMEA/FMECA, PM optimization, predictive maintenance, and condition-based maintenance approaches.

Lead Asset Performance Monitoring and PlantPulse adoption

• Define business requirements for asset health, criticality, failure modes, risk ranking, performance monitoring, and continuous improvement.
• Partner with SAP EAM, Technology/IS, site engineering teams, the Reliability Network, and SMEs to support deployment, training, adoption, and data quality.
• Serve as PlantPulse business owner to ensure tools address reliability pain points, support troubleshooting, and generate actionable equipment insights.

Connect reliability to business value

• Partner with OPEX teams to identify reliability improvements that unlock capacity and reduce downtime.
• Translate recurring failures and reliability constraints into business impact.
• Support lifecycle risk visibility for critical assets, including deterioration, obsolescence, maintenance cost, reliability concerns, and end-of-life planning.
• Integrate reliability principles into capital projects from conceptual design through turnover.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Principal Engineer professional we seek is a collaborative individual contributor leader with these qualifications.

Basic Qualifications:

Doctorate degree & 2 years of engineering industry experience

OR

Master’s degree & 4 years of engineering industry experience

OR

Bachelor’s degree & 6 years of engineering industry experience

OR

Associate’s degree & 10 years of engineering industry experience

OR

High school diploma/GED & 12 years of engineering industry experience

Beyond that, additional preferred qualifications are:

• Bachelor’s degree in Engineering.
• Experience in maintenance, reliability, engineering, asset management, manufacturing operations, and/or engineering digital transformation.
• Experience leading cross-functional initiatives in site, multi-site, or global environments.
• Strong knowledge of CMMS/EAM and asset performance monitoring systems, such as SAP, Maximo, or equivalent.
• Working knowledge of asset criticality, RCM, FMEA/FMECA, RCA, PM optimization, PdM, condition-based maintenance, and reliability KPIs.
• Ability to translate site needs into scalable business processes, digital product requirements, and improvement actions.
• Strong stakeholder management, communication, network leadership, and change leadership skills.
• Experience with analytics or dashboarding tools such as Power BI, Spotfire, SAP Analytics Cloud, or equivalent.
• Experience in GMP, biopharmaceutical manufacturing, GxP research, laboratory, or other regulated operations.
• Familiarity with ISO 55000, ISO 14224, SMRP, Uptime Elements, or similar reliability and asset management frameworks.
• Certification such as CMRP, CRL, PMP, Lean Six Sigma, or asset management certification.
• Experience deploying predictive maintenance, condition monitoring, smart sensors, AI-enabled analytics, or advanced asset health technologies.
• Experience developing business cases for reliability, maintenance, lifecycle asset management, or capacity improvement projects.
• Fluent English proficiency, written and verbal.
• Availability to commute to the nearest Amgen operation site as business needs arise, including for meetings, training, operational support, or other business-critical activities.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental & vision coverage, and life & disability insurance
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

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Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.