Sr. Principal Scientist - Precision Medicine Translational Target Discovery

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr. Principal Scientist - Precision Medicine Translational Target Discovery

What you will do

Let’s do this. Let’s change the world. Precision Medicine is seeking an innovative scientist to drive novel target discovery at the intersections of translational research, human genetics and disease biology. In this vital role you will validate novel target nominations supported by real world evidence and human genetics through functional and mechanistic investigation. This individual will lead a small team of experimental biologists integrated within a broader collaborative target discovery working group spanning therapeutic areas and modalities, computational biology, precision medicine and the human genetics team at deCODE genetics. Success in these efforts will have the impact of advancing novel targets into drug development and ultimately the clinic

Example focus areas include:

• Understanding disease associated mechanisms of genetically nominated targets
• Identifying targetable pathways and implicated cell types from human genetic studies
• Elucidating mechanisms of disease associated variants through genetic engineering
• Applying functional genomics to uncover the role of non-coding regulatory elements
• Developing chemical genetic strategies to model and assess the consequences of pharmacological target modulation

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience

Or

Master’s degree and 6 years of directly related experience

Or

Bachelor’s degree and 8 years of directly related experience

Preferred Qualifications:

• MD or PhD + >2 years industry or academic experience
• Excellence in the method and logic of experimental biology
• Experience in target discovery, drug discovery and/or therapeutics
• Ability to develop rigorous analysis plans and to interpret experimental results through statistical and quantitative approaches
• Proven ability in written or oral scientific communication – a strong record of scientific publication or presentation
• Strong track record of mentorship at the bench
• Highly adaptable individual with a firm grounding in the fundamentals of genetics, molecular biology and target discovery.
• Demonstrated experience in hypothesis development and experimental design is crucial as is the desire to lead from the front and generate data necessary to test therapeutic hypotheses.
• A highly collaborative leader able to simplify and unambiguously communicate data, logic and strategy across a diverse team environment.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.number of candidates.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.