Oligonucleotide Chemist

Category: Research
Job ID: R-57997
Location: US – California – Thousand Oaks
Posted Date: June 11, 2018

Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions.

To underpin our commitment to serve patients, Amgen is hiring in the department of Therapeutic Discovery at our Research and Development facility in Thousand Oaks, CA (ATO).

This Scientist will be part of an innovative and interdisciplinary Hybrid Modality Engineering group, with responsibilities including the design, synthesis, and purification of novel compounds for delivery of oligonucleotides, novel chemical modifications, mechanistic understanding of RNAi, and potential clinical drug development with the opportunity to directly interact with project teams that include members from therapeutic areas, PKDM, toxicology, and legal groups.

The successful candidate will have a strong experimental background in oligonucleotide chemistry and biochemistry through hands-on experience in several areas including synthetic organic chemistry, nucleoside modifications, oligonucleotide conjugation, chemical and biophysical characterizations and bring a rigorous, analytical approach to problem solving and experimental design.

Summary of Key Responsibilities

Develop and execute synthesis of novel chemical modifications and delivery modalities for siRNA

Synthesis, purification, and analysis of nucleoside and nucleotide analogs

Synthesis of lipids, carbohydrates and other building blocks to be used for RNA delivery

Prepare clearly articulated experimental reports and data presentations

Analyze, interpret, and organize data to present in internal meetings.

Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international scientific meetings; providing scientific results that support the generation of publications, patents, or regulatory submissions and mentoring research associates and laboratory assistants.

Basic Qualifications

Doctorate degree or Doctorate degree completed by August 2018

OR

Master’s degree and 4 years of scientific experience

OR

Bachelor’s degree and 6 years of scientific experience

Preferred Qualifications

PhD in Chemistry and 1+ years of post-degree laboratory research experience with emphasis in nucleoside/oligonucleotide chemistry in an industrial or academic setting

Strong experience in organic chemistry and multi-step organic synthesis; experience in chemistry of nucleosides and nucleotides, nucleic acid modifications, and delivery of oligonucleotides

Strong laboratory skills in synthesis, purification, and characterization of small molecules and oligomers, expertise in state of the art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data

Flexible to be able to apply knowledge to new areas of study, thrive in a team environment, and possess excellent communication skills (both written and oral)

Proven track record of academic accomplishments (i.e., peer-reviewed publications and/or patents)

Demonstration of good lab practices, with particular attention to safety

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status.

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