The Scientist will be directly responsible for executing in vivo cardiovascular PK/PD studies with a goal to identify innovative drug therapies for the treatment of heart-related conditions. The Scientist will work with preclinical in vivo models for testing therapeutic concepts and will utilize strong, hands-on technical skill set of in vivo capabilities supporting research studies in relevant therapeutic areas.
Working cross-functionally within Amgen and interacting closely with Discovery Research groups, the Scientist will assist in designing in vivo experiments, drafting and implementing protocols, executing studies, organizing data, analyzing results, and drafting reports/delivering presentations.
Executing in vivo cardiovascular PK/PD studies with a goal to identifying novel drug candidates
Routine dose administration (IV, PO, SC etc.)
Tissue and fluid sampling
Catheterization of major vessels for dosing/sampling
Aseptic surgical/microsurgical experience
Working knowledge of the application/use of IACUC protocols
In vivo assessment of cardiovascular hemodynamics using echocardiography, invasive hemodynamics (PV loop methodology), other cardiac imaging methodologies (e.g. MRI)
Surgical and pharmacological models of induced cardiac dysfunction
Ex vivo assays (e.g. Langendorff/working heart prep) for the evaluation of cardiovascular physiology
Master’s degree and 4 years of scientific experience
Bachelor’s degree and 6 years of scientific experience
Experience leading and performing in-life research studies
Demonstrated ability to function optimally in a team-based/collaborative environment
Ability to problem solve independently and contribute scientifically to the research goals of the cardiovascular group
Possess scientific leadership ability, including analytical and critical thinking skills, quick learning abilities and the ability to propose and implement scientific ideas consistent with the strategic direction
Ability to critically review published literature and independently validate published findings
Awareness of processes related to target identification and validation
Communicate effectively both verbally and in writing with attention to detail and competencies with database, spreadsheet and presentation applications (i.e. Excel, PowerPoint, Data entry systems).
Possess strong interpersonal skills, self-motivation and the ability and willingness to work independently, and handle multiple (multi-task) and changing priorities in line with fluctuations in the work load.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.